Experience true Southern hospitality at Guesthouse Charleston, a luxurious boutique vacation rental agency in the heart of the Lowcountry. Our rich accommodations, warm hospitality, and prime location in downtown Charleston make us the perfect choice for your stay.

Whether you're here for work or play, our group housing blocks and beautifully furnished spaces cater to any occasion. Enjoy the comforts of home with the service of an upscale hotel.

Book your stay at Guesthouse Charleston and experience luxury, comfort, and unparalleled service. Be our guest and unlock an extraordinary stay in Charleston.